Consequently, it truly is conceivable which the JIP1/3???ASK1???MKK4 signaling module might serve as a conduit to activate JNK when endosomal trafficking is disrupted and glucose degrees drop throughout the early stages of methuosis. Our obtaining that MKK4 was robustly activated from the methuosis-inducing IPPs, MOMIPP and 2q, and fewer so with th